Heterogeneity of Fibroblasts in Healthy and Diseased Kidneys

Chronic kidney disease (CKD) is a worldwide health problem affecting 9.1% of the world’s population. The treatments to prevent progression CKD remain limited, however. Resident fibroblasts in kidneys play crucial roles pathological conditions commonly recognized CKD, such as renal fibrosis, anemia, and peritubular capillary loss. Fibroblasts provide structural backbone by producing extracellular matrix proteins produce erythropoietin for normal hematopoiesis under physiological conditions. In diseased condition, however, differentiate into myofibroblasts that excessive at cost inherent erythropoietin-producing abilities, resulting fibrosis anemia. Pericytes, which are mesenchymal cells enwrap capillaries highly overlap with resident fibroblasts, detach from walls response injury, loss tissue hypoxia. Several reports have demonstrated beneficial regeneration tubules Renal also potential proinflammatory state, various cytokines chemokines prolonging inflammation forming tertiary lymphoid tissues, functional aggregates, some this article, we describe heterogenous functions healthy